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 721 Cyto Intracellular Amplifier

  
  An economy version of the Intra 767 low noise wide-band probe electrometer for intracellular research including variable filtering with current injection for microiontophoresis, bridge balancing and capacitance compensation with microelectrode insertion features (tickling)  

Low Noise Headstage — A miniature sealed gold plated probe contains the active headstage low noise FET, specially designed to minimize power line frequency noise and electrode capacitance.

Removable Microelectrode Holder — WPI’s specialized Ag/AgCl half-cell microelectrode holders plugs directly into the probe on a 2mm pin. A wide variety of holders are available for many applications.

Driven Guard Shield — Stray electrode capacitance is reduced by placing the included driven guard shield over the microelectrode holder at the input end of the probe.

Current Injection — Two ranges of current delivery are provided: 500 nA and 5 µA or by injecting from or with an external supply. The current injection can be used for delivering hyperpolarizing currents to stabilize cell membrane potential or to provide current for microiontophoresis of drug or dye injection.

Compliance Alarm — An audible compliance alarm will sound if the electrode voltage exceeds the system maximum.

Breakaway Mode — In applications where the required current or the microelectrode resistance renders the 10-volt system compliance limit insufficient, the built-in “breakaway” feature may be used, allowing direct access to the electrode tip via a 2M resistor. Up to 200 V may then be applied to the electrode without damaging the electrode electronics.

Bridge Balance — All currents developed by the internal DC and external generator and the external command are fed through an active bridge balance circuit which subtracts the artefacts associated with delivering current through the recording micropipette. The bridge can balance electrode resistances up to 100 megaohms or 1000 megaohms in two ranges.

Multiple Gain Outputs — Outputs from the bridge circuit are located on the front panel (gain) and the rear panel (1x, 10x, 20x or 50x).

Probe Test Port — Allows testing and alignment of the headstage prior to connection to the preparation.

Capacity Compensation — The built in amplifier can neutralize up to 50 pF of electrode shunt capacitance.

Tickler — The tickler circuit in the Cyto 721 generates oscillations under precise control and facilitates penetration of the cell membrane while minimizing cell damage. Both the frequency and amplitude of oscillations are easily adjustable from the front-panel. A remote logic control allows for manual or computer activation.
     
 

 

SPECIFICATIONS
INPUT RESISTANCE > 1011 Ohms
OUTPUT IMPEDANCE 100 Ohms
GATE LEAKAGE CURRENT 1pA max (adjustable to zero)
GAINS
Front Panel 1x output: 1 ± 0.1%
10x output: 10 ± 0.1%
Rear Panel 20x or 50x, switch selectable ± 0.1%
INPUT VOLTAGE RANGE 10 V (maximum input 15 V)
RISETIME 1.0 µs (10-90%) voltage step applied directly to the input, 25 µs (10-90%) voltage step applied through a 20 M Ohms metal film resistor, input compensated for zero overshoot.
BANDWIDTH 20 kHz (Through 20 M Ohms input compensated for zero overshoot)
NOISE LEVEL 25 µV p-p typical; input shorted (DC-10 kHz@ 1x output) 250 µV p-p typical through 20 M Ohms source resistance (DC-10 kHZ @ 1X)
CAPACITANCE COMPENSATION Negative: 0-50 pF, Positive: 0-10 pF
TICKLER Adjustable frequency and amplitude, manual or remote operation
OSCILLATION FREQUENCY RANGE 1-8 kHz
AMPLITUDE RANGE 1-10V
REMOTE INPUT REQUIREMENTS 2.5V min, 10 ms min
CURRENT INJECTION RANGES
External Command (low range) ±10 V ÷ microelectrode resistance or 500 nA, whichever is lower.
External Command
(high range) 		±10 V ÷ microelectrode resistance or 5 µA, whichever is lower.
Internal D.C. ±50 nA (low range), ±500 nA (high range)
Breakaway I = Applied Voltage ÷ 2M Ohms + Microelectrode Resist. (V ±200V)
ELECTRODE RESISTANCE TEST 1 mV/M Ohms @ 1x output
DC POSITION RANGE ± 300 mV @ 1x output
BANDWIDTH FILTERS Continuously variable active filter (low pass) 1-30 kHz, 40 dB/decade
BRIDGE BALANCE RANGES 0-100 M Ohms and 0-1000 M Ohms, switch selectable
METER
Display 3.5-digit LED
Ranges 200 mV, 2000 mV , 20V, 200 nA, 2000 nA
POWER 95-135 V or 220-240 V, 50/60 Hz
DIMENSIONS 17 x 5.25 x 10 in. (43.2 x 13.4 x 25.4 cm)
SHIPPING WEIGHT 15 lb (6.8 kg)

 

MODELS
721 Cyto 721 Electrometer

 
| Rack Mounts | Cables and Connectors | Manual 
                             Note that WPI Equipment is NOT Designed for Human Use

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