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 DVC-1000
Two-Channel Voltage/Current Clamp |
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WPI's
DVC-1000 is well-known and widely used for studying
epithelial tissues. |
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Each
DVC-1000 consists of two separate clamp instruments -- One
for clamping a control tissue, another for clamping a test
tissue. This dual clamp technique lets you monitor changes
in membrane permeability as a function of voltage or
applied chemical agents.
Either
clamp unit operates in five modes. Voltage clamp: Clamps
the tissue voltage to a given level and displays the
current required to maintain that level. Amplify: Shows
the potential difference between the two voltage
electrodes. Current clamp: Lets you deliver a constant
current between the two current electrodes while
simultaneously monitoring voltage changes at the tissue
Timer:
Functions in either current clamp or voltage clamp
experiments, letting you cycle automatically between zero
clamp and a preset clamp level. Remote: Allows you to
control clamp operation from a computer or other logic
level source.
Small
preamplifiers (included) which mount close to the chamber
let you connect to voltage and current electrodes without
long cables or agar bridges. DVC-1000 also features a
unique ±100 V power supply capable of delivering up to 1
mA of clamp current. Each clamp lets you correct for input
offset voltages and fluid resistance error.
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1.
Hautefeuille M.,
et al., (1986) "In vitro effects of b-casomorphin
on ion transport in rabbit ileum". The Amer.
Physiol. Soc. 0193-1857/86, G92-G97.
2.
Heyman M., et al., (1994) "Mononuclear
Cells from Infants allergic to Cow's Milk Secrete
Tumor Necrosis Factor a, Altering intestinal
Function". Gastroenterology, 1514-1523.
3. MacVinish, L.J., et al., (1997)
"Normalization of ion transport in murine cystic
fibrosis nasal epithelium using gene transfer". The
Amer. Physiol. Soc. Special Communication 0363-6143/97,
C735-C740.
4. Mahraoui, L., et al., (1997) "Apical
effect of diosmectite on damage to the intestinal
barrier induced by basa tumour necrosis
factor-a". GUT, Vol 40, N° 3, pp
339-343.
5. MacVinish, L.J., et al., (1998)
"Importance of basolateral K+ conductance in
maintaining CL- secretion in murine nasal and colonic
epithelia". J. Physiol, 510.1,
pp.237-247.
6.
Matysiak-Budnik T., et al., (1998)
"Helicobacter pylori Exogenous Antigen Absorption
and Processing in a Digestive Tract Epithelial cell
line Model". Infection and Immunity, pp
5785-5791.
7.
Sari, A., et al., (1998) "Tetracycline
Stimulates Chloride Secretion Through ORCC Channels
Activations in Human Nasal Epithelial Cells". Pediatric
Pulmonology, Supp 17, 231.
8. Boisset, M., Botham, R. P., Haegele, K. D.,
Lenfant, B., Pachot, J.
I. “Absorption of angiotensin II antagonists in
Ussing chambers, Caco-2, perfused jejunum loop and in
vivo: Importance of drug ionisation in the in vitro
prediction of in vivo absorption” (2000) European
Journal of Pharmaceutical Sciences 10:3
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Rack
Mounts
| PRO4
Timer
| Cables and Connectors
| Manual |
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français
+49
(0)30 6188845
+45 (0)36 988 355
