

FD223a
Dual Channel Differential Electrometer
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Overview

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FD223a Datasheet
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FD223a Instruction Manual
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Electrochemical measurements with ion specific electrodes
- Dual channel with very high input impedance
- Separate outputs for Channel A, B and A-B (Differential)
- Independent DC offset controls
- Test port
- Standby mode
Benefits
- Measure changes in intracellular ion content electrochemically
- Stable and drift free
- Excellent amplification with low noise
- Driven guard shield for reduced noise and stray capacitance
- Set probe leakage current
Applications
- Measure intracellular ion concentrations for K+, Ca2+, H+ and other species
FD223A Dual Channel Differential Intracellular Amplifier
The FD223a is a dual differential, high impedance amplifier/electrometer designed specifically for electrochemical measurements using ion specific (K+, Na+, Cl-, etc.) or pH glass microelectrodes.
The instrument is very stable, drift free, and features a built in provision for measuring and adjusting input leakage current. DC levels may be independently adjusted for each probe channel.
The ability to locate the sensing probes directly at the measurement site overcomes the noise introduced by the long cables usually needed to bring the measured potential to the instrument. Signal-driven guards at the probe input maintains the specified high resistance and reduces the stray capacitance of the probes.
Careful design, coupled with quality component selection, particularly in the headstage, results in an excellent amplifier with low noise and wide bandwidth. The FD223a will faithfully reproduce the measured signal.
To reduce the noise and stray capacity even farther the probe housing includes a signal driven guard. A portion of this inner driven shell is exposed at the probe tip allowing a spring shield to be extended over the electrode holder and microelectrode.
Specifications
Input Impedance | > 1015 Ω, shunted by 0.5 pF |
Input Capacitance | 1 pF, nominal |
Leakage Current | 75 fA max |
Gain | 1.000 ± 0.1% |
Output Resistance | 50 Ω |
Input Swing Voltage | ±10 V |
Rise Time (10 to 90%) | 5 µs, small signal |
Noise (0.1 Hz to 10 kHz) | |
Baseline Stability | ±0.1 mV/day |
Position Controls Range | ±600 mV |
Physical Dimensions | Case: 8.8 x 21.0 x 17.5 cm (H x W x D) Probe:12.7 x 65 mm (D x L), 1.8 m cable |
Power | 90-265 VAC, 50/60 Hz, 10 VA |
Probe Handle | 6.5 x 65 mm (D x L) |
Shipping Weight | 2.5 kg |
Operating Conditions | Equipment is intended to be operated in a controlled laboratory environment. Temperature: 0-40°C; altitude: sea level to 2000 m; relative humidity: 0-95%. |
Accessories
Citations
Interactions of Aging and Hydrogen Peroxide on Pulmonary Vein Electrical Activity: Implications in the Pathophysiology of Atrial Fibrillation | Request PDF. (n.d.). Retrieved November 27, 2018, from https://www.researchgate.net/publication/265121078_Interactions_of_Aging_and_Hydrogen_Peroxide_on_Pulmonary_Vein_Electrical_Activity_Implications_in_the_Pathophysiology_of_Atrial_Fibrillation
MacMillan, H. A., Andersen, J. L., Davies, S. A., & Overgaard, J. (2016). The capacity to maintain ion and water homeostasis underlies interspecific variation in Drosophila cold tolerance. Scientific Reports, 5(1), 18607. https://doi.org/10.1038/srep18607
Fernandes de Lima, V. M., Piqueira, J. R. C., & Hanke, W. (2015). The Tight Coupling and Non-Linear Relationship between the Macroscopic Electrical and Optical Concomitants of Electrochemical CNS Waves Reflect the Non-Linear Dynamics of Neural Glial Propagation. Open Journal of Biophysics, 05(01), 1–20. https://doi.org/10.4236/ojbiphy.2015.51001
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Argenziano, M., Tiscornia, G., Moretta, R., Amorena, C. E., & García Gras, E. (2014). Hormonal Control of Cardiac Action Potential Phase 1 Currents in the Brugada Syndrome. Argentine Journal of Cardiology, 82(4), 310–315. https://doi.org/10.7775/ajc.82.4.3885
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