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Nicholas James, King's College London

Customer service was always quick and very helpful. Products all arrived quickly, were fully set up for us and have proved to be of good quality.
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II-MRBP-R

II-MRBP-R

Blood Pressure Monitor - Rat

  • Overview
  • Specifications
  • Accessories
  • Citations
  • Related Products

Overview

MRBP system

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Data Sheet
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  • Quick and accurate blood pressure measurement
  • Highly sensitive photoelectric sensor for blood pressure detection
  • Monitor, record, store or export real time systolic, diastolic, mean and heart rate

 

  • Includes all accessories necessary to run system
  • Test up to 200 animals at a time
  • Sensor is MRI compatible
  • Quick and accurate blood pressure measurement at temperatures as low as 32°C
  • Highly sensitive photoelectric sensor for blood pressure detection
  • Monitor, record, store or export real time systolic, diastolic, mean and heart rate
  • Multi-channel system available

This revolutionary design brings non-invasive blood pressure testing to a new level — a true turn-key system for accurate, consistent blood pressure measurement on mice, rats or any other laboratory animal test subject.

It is a compact, simple yet versatile system that can test from one to 200 animals at a time with independent control of each channel. Simple daisy-chaining allows expansion of up to 200 independently controlled systems.

All components are built into one small unit — controls, inflation of tail cuff, warming environment with whisper-quiet fans — providing an ideal system for teaching facilities and for the pharmaceutical industry when high throughput is a must.

Single animal systems are controlled from the touch screen, which allows keying in all necessary test setups. Touch screen control allows ease of operation, supplying automatic evaluation of test results — systolic, diastolic, mean and heart rate.

Data is collected, stored, displayed and can be transferred to the supplied memory stick. The USB interface allows for software control of multi-channel systems. For single animal systems, built-in software lets you view and export data. Reports are in an Excel-style format and may be easily exported.

No computer is required. However, the analog output may be interfaced with your own data acquisition software.

The system is easily cleaned. Removable trays are included with each system.

In addition to the standard one-year warranty on the system, tail cuff sensors have a lifetime warranty.

How it Works

Place an animal in the supplied restrainer, attach tail cuff, set the desired temperature of the warming chamber, select number of test cycles, press auto calibrate and run test. The tail cuffs require the minimum amount of heat to measure blood pressure. The average temperature for rats is 32ºC and for mice 34ºC. The tail cuff design consists of a photoelectric cell, the most accurate method for obtaining tail cuff blood pressure pulses. Other systems heat metal platforms to as high as 40ºC to take measurements, causing undo thermo stress.

Warming Chamber

The warming chamber is an independent environment that you control through the touch screen interface. Heating plates and room temperature are not a factor. Warm air is delivered to the housing by a small fan which generates a calming “white noise” resulting in consistent and accurate readings.

Software

When testing multiple animals, the system is supplied with the proprietary blood pressure software which allows for complete control of all functions and parameters from the software.  All data is shown,

Specifications

Accessories

Citations

Alashi, A., & Blanchard, C. (2014). Blood pressure lowering effects of Australian canola protein hydrolysates in spontaneously hypertensive rats. Food Research  …. Retrieved from https://www.sciencedirect.com/science/article/pii/S0963996913006145

Baudrand, R., Lian, C., & Lian, B. (2014). Long-term dietary sodium restriction increases adiponectin expression and ameliorates the proinflammatory adipokine profile in obesity. Nutrition, Metabolism  …. Retrieved from https://www.sciencedirect.com/science/article/pii/S0939475313001877

Bunbupha, S. (2014). Asiatic Acid Reduces Blood Pressure by Enhancing Nitric Oxide Bioavailability with Modulation of eNOS and p47phox Expression in l-NAME-induced Hypertensive. Phytotherapy  …. Retrieved from https://onlinelibrary.wiley.com/doi/10.1002/ptr.5156/full

Chen, G., Pan, S., & Shen, C. (2014). Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways. Acta Pharmacologica  …. Retrieved from https://www.nature.com/aps/journal/vaop/ncurrent/full/aps2013185a.html

Deng, J., Lee, S., Kuo, W., & Fan, M. (2014). Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts. Chemico-biological  …. Retrieved from https://www.sciencedirect.com/science/article/pii/S0009279713003190

Dudhipala, N., & Veerabrahma, K. (2014). Candesartan cilexetil loaded solid lipid nanoparticles for oral delivery: characterization, pharmacokinetic and pharmacodynamic evaluation. Drug delivery. Retrieved from https://informahealthcare.com/doi/abs/10.3109/10717544.2014.914986

Fioresi, M., Simões, M., & Furieri, L. (2014). Chronic Lead Exposure Increases Blood Pressure and Myocardial Contractility in Rats. PloS one. Retrieved from https://dx.plos.org/10.1371/journal.pone.0096900.g005

Freundlich, M., Li, Y., & Quiroz, Y. (2014). Paricalcitol downregulates myocardial renin–angiotensin and fibroblast growth factor expression and attenuates cardiac hypertrophy in uremic rats. American journal of  …. Retrieved from https://ajh.oxfordjournals.org/content/27/5/720.short

Jensen, I., Eysturskarð, J., Madetoja, M., & Eilertsen, K. (2014). The potential of cod hydrolyzate to inhibit blood pressure in spontaneously hypertensive rats. Nutrition Research. Retrieved from https://www.sciencedirect.com/science/article/pii/S0271531713002704

Khan, M., & Neckár, J. (2014). Azilsartan Improves Glycemic Status and Reduces Kidney Damage in Zucker Diabetic Fatty Rats. American journal of  …. Retrieved from https://ajh.oxfordjournals.org/content/early/2014/03/11/ajh.hpu016.short

Kriska, T., & Cepura, C. (2014). Role of macrophage PPARγ in experimental hypertension. American Journal of  …. Retrieved from https://ajpheart.physiology.org/content/306/1/H26.abstract

Patel, V., Clarke, N., Wang, Z., & Fan, D. (2014). Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS. Journal of molecular and …. Retrieved from https://www.sciencedirect.com/science/article/pii/S0022282813003507

Rajeshwari, T., & Raja, B. (2014). Valproic acid attenuates blood pressure, vascular remodeling and modulates ET-1 expression in L-NAME induced hypertensive rats. Biomedicine & Preventive …. Retrieved from https://www.sciencedirect.com/science/article/pii/S2210523913000585

Rogers, J., & Ellis-Hutchings, R. (2014). Elevated blood pressure in offspring of rats exposed to diverse chemicals during pregnancy. Toxicological  …. Retrieved from https://toxsci.oxfordjournals.org/content/137/2/436.short

Siew-Keah, L., & Sundaram, A. (2014). Effect of melatonin supplementation and cross-fostering on renal glutathione system and development of hypertension in spontaneously hypertensive rats. Journal of physiology  …. Retrieved from https://link.springer.com/article/10.1007/s13105-013-0282-3

Silveira, E., & Siman, F. (2014). Low-dose chronic lead exposure increases systolic arterial pressure and vascular reactivity of rat aortas. Free Radical Biology  …. Retrieved from https://www.sciencedirect.com/science/article/pii/S0891584913015268

Tan, S., Song, E., & Dong, X. (2014). Peripheral GABA< sub> Areceptor activation modulates rat tongue afferent mechanical sensitivity. Archives of oral  …. Retrieved from https://www.sciencedirect.com/science/article/pii/S000399691300352X

Wang, Y., Mu, J., Liu, F., & Ren, K. (2014). Salt-induced epithelial-to-mesenchymal transition in Dahl salt-sensitive rats is dependent on elevated blood pressure. Brazilian Journal of  …. Retrieved from https://www.scielo.br/scielo.php?pid=S0100-879X2014000300223&script=sci_arttext

Ware, K., & Vance, J. (2014). Oral Warfarin and the Thrombin Inhibitor Dabigatran Increase Blood Pressure in Rats: Hidden Danger of Anticoagulants? American Journal of …. Retrieved from https://ajh.oxfordjournals.org/content/early/2014/07/11/ajh.hpu129.short

Zerbinati, N., Marotta, F., & Nagpal, R. (2014). Protective Effect of a Fish Egg Homogenate Marine Compound on Arterial Ultrastructure in Spontaneous Hypertensive Rats. Rejuvenation  …. Retrieved from https://online.liebertpub.com/doi/abs/10.1089/rej.2013.1494

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Blood Pressure Monitor - Mouse

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