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CW-MICROCAPSTAR

CW-MICROCAPSTAR

CO2 Analyzer for Small Animals


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Overview

CW-MICROCAPSTAR

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Data Sheet
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  • End-tidal peak or continuous readings
  • Low sample flow requirements
  • Accurate and stable monitoring
  • Simple one-gas calibration
  • Linear output signal for recording

The MICROCAPSTAR End-Tidal Carbon Dioxide Analyzer provides accurate end-tidal or continuous measurement of expired CO2 in animals as small as mice. It features very low sample flow requirements, rapid response time, and long-term stability. Respiratory rate (RR) is computed using the excursions of the CO2 waveform. The CO2 and RR measurements, as well as a trend plot of the end-tidal values, are displayed on the graphics LCD screen.

The heart of the MICROCAPSTAR is a new temperature-controlled, miniature infrared CO2 sensor with digital output. Low sample flow and rapid response is achieved with a carrier gas system employing digitally controlled active flow management. This technique precisely and automatically maintains the ratio of carrier flow to sample flow, which is essential for accurate measurements.

The heated measurement cell prevents water condensation, even during longterm measurement sessions. The front-panel display shows CO2 concentration (either instantaneous or ETCO2) in either percent or mmHg. Calibration is performed with a single calibration gas and room air. An adjustable ETCO2 alarm provides a warning when end-tidal values fall out of a useradjustable preset range. All adjustments are performed digitally using a single knob. Built-in diagnostics monitoring warn of plugged sample tubing or other fault conditions.

The advanced features, reliability, and ease of operation of the MICROCAPSTAR make it the perfect companion to our SAR-830 series Small Animal Ventilators for monitoring respiratory status. An accessory pack containing spare low volume sample tubing and a variety of connectors and fittings is included with the instrument. A range of accessories is available to ensure easy setup and convenient operation. Windows-based monitoring software is included, which allows display of the measurements, and saving the data to a disk file.

Specifications

CO2 Measurement single beam, non-dispersive infrared
Measurement range  0 - 9.9% (0 - 76.0mmHg)
CO2 Accuracy  0.15% (1.1mmHg)
Resolution (internal and analog output)  0.01% (0.1mmHg)
Resolution (display)  0.1% (1.0mmHg)
Linearity  0.1% CO2
Repeatability  0.1% CO2
Response time (T10 - T90)  75mS at 70 ml/min through cell
Sample cell materials  sapphire and stainless steel
Analog output scaling  1.1V/% (0-10V)
Response time (T10 - T90)  150mS at 50 ml/min sampling
Zero stability  0.2% (8 hours), 0.3% (24 hours)
Interference effects: 50% N2O  0.1% at 0% CO2, 0.6% at 5% CO2 (uncomp.)
Maximum sample cell pressure  +5 psig
Interference effects: vaporized anaesthetic agents  negligible
Operating temperature range  5-40°C
Optical bench temperature  48°C, controlled
Warm-up time  4 min to 0.2%, 10 min to 0.1%
ETCO2 trend display  5 minute graphical scrolling display
Sample flow (sample inlet - carrier flow out)  10ml/min nominal, adjustable from 5.0 - 20ml/min
Sample tubing connections (carrier flow, sample inlet)  Luer female
Calibration controls  Zero, Span
ETCO2 alarm adjustment range  1.0 - 9.9% (8 - 75mmHg)
Respiratory rate measurement range  5 - 200 breaths/min
Signal outputs (rear panel)  BNC jacks
CO2 output scaling  1.0V / %CO2
Respiratory rate output scaling  0.05V / bpm
Alarm output  5V if alarm condition, 0V if no alarm
Serial data output format  2400 baud, 8 data, no parity, 1 stop bit
Electrical requirements  120VAC/220VAC switchable, 35VA
Dimensions  19W x 5.25H x 16D in., 49W x 13H x 41D cm
Weight  10 lbs. (4.5kg)

Accessories

Citations

Kim, J., & Jeong, Y. (2013). Augmentation of Sensory-Evoked Hemodynamic Response in an Early Alzheimer’s Disease Mouse Model. Journal of Alzheimer’s Disease. Retrieved from https://iospress.metapress.com/index/H2KQ18756J7L5T37.pdf

Luckett, B., & Frielle, J. (2013). Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin. American Journal of  …. Retrieved from https://ajpheart.physiology.org/content/304/11/H1538.short

Perles-Barbacaru, T. (2012). Quantitative pharmacologic MRI in mice. NMR in  …. Retrieved from https://onlinelibrary.wiley.com/doi/10.1002/nbm.1760/full

Sabino, J., Oliveira, M. de, & Giusti, H. (2013). Hemodynamic and ventilatory response to different levels of hypoxia and hypercapnia in carotid body-denervated rats. Clinics. Retrieved from https://www.scielo.br/pdf/clin/v68n3/a19v68n3.pdf

Sabino, J., Silva, C. da, & Giusti, H. (2013). Parasympathetic activation by pyridostigmine on chemoreflex sensitivity in heart-failure rats. Autonomic  …. Retrieved from https://www.sciencedirect.com/science/article/pii/S1566070213006024

Shih, A., Driscoll, J., & Drew, P. (2012). Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain. Journal of Cerebral  …. Retrieved from https://www.nature.com/jcbfm/journal/vaop/ncurrent/full/jcbfm2011196a.html

Srienc, A., Kornfield, T., & Mishra, A. (2012). Assessment of glial function in the in vivo retina. Astrocytes. Retrieved from https://link.springer.com/protocol/10.1007/978-1-61779-452-0_33

Zhang, Z., Zhang, C., Zhou, M., & Xu, F. (2012). Activation of opioid μ-receptors, but not δ-or κ-receptors, switches pulmonary C-fiber-mediated rapid shallow breathing into an apnea in anesthetized rats. Respiratory Physiology & Neurobiology. Retrieved from https://www.sciencedirect.com/science/article/pii/S1569904812001917

Zhuang, J., & Zhang, Z. (2012). 8-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT1A receptors in the nucleus tractus solitarius. American Journal of  …. Retrieved from https://ajpregu.physiology.org/content/303/4/R449.short

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