World Precision Instruments

Search the site by KEYWORD


Quick Finder


Testimonials

Nicholas James, King's College London

Customer service was always quick and very helpful. Products all arrived quickly, were fully set up for us and have proved to be of good quality.
read more

MCB1-200

MCB1-200

MechanoCulture B1 - Biaxial stimulation of a cells in a monolayer or 3D matrix



Choose Quantity
  • Overview
  • Specifications
  • Accessories
  • Citations
  • Related Products

Overview

Snowflake Assembly assures uniform force distribution

There are 2 images available to view - click to enlarge and scroll through the product gallery.

Data Sheet
/ Download as PDF

  • Biaxial stimulation of a cells in a monolayer or 3D matrix

 

The MCB1 uses a complex deformable interface to generate radial motion patterns on a 24-pin mounting ring.  User-supplied 35mm diameter membranes, scaffolds, and tissues can be puncture-mounted to this ring and biaxially stretched according to the specified protocol.  The entire assembly can be sterilized and is suitable for long-term cell culture in a laboratory incubator.

Key Features

 

  • Biaxial stretch up to 20%
  • Compatible with a wide range of materials including silicone membranes, decellularized tissues, hydrogels, electrospun materials, and more.
  • PC-independent operation
  • User-friendly interface software for specifying simple, cyclic, and intermittent stimulation protocols for download to the device controller

 

 

Specifications

Dimensions 22 X 10 X 4cm
Weight 1 kg
Stimulation Mode Biaxial tension
Configuration Cell monolayer, 3D constructs and tissues
Culture Area 1 well, 35mm diameter
Maximum Strain 20% biaxial
Maximum Velocity 10mm/s
Maximum Cycle Frequency 2Hz
Loading Capacity 10N
Media Volume/well 0.5-100mL

Accessories

Citations

Rashika Joshi, Matthew R. Batie, Qiang Fan, and Brian Michael Varisco* (2021). Mouse Lung Organoid Responses to Reduced, Increased, and Cyclic Stretch. American journal of physiology. Lung cellular and molecular physiology vol. 322,1 (2022): L162-L173. doi:10.1152/ajplung.00310.2020

Xun Xu, Yan Nie, Weiwei Wang, Nan Ma & Andreas Lendlein  (2021). Periodic thermomechanical modulation of toll-like receptor expression and distribution in mesenchymal stromal cells. MRS communications, 1-7. 8 Jul. 2021, doi:10.1557/s43579-021-00049-5

Kim, M.K.M., Burns, M.J., Serjeant, M.E. and Séguin, C.A., (2020). The mechano-response of murine annulus fibrosus cells to cyclic tensile strain is frequency dependent. JOR spine vol. 3,4 e21114. 20 Jul. 2020, doi:10.1002/jsp2.1114

O. Friedrich, A-L. Merten, D. Schneidereit, Y. Guo, S. Schurmann, N. Martinac (2019). Stretch In Focus: 2d Inplane Cell Stretch Systems For Studies Of Cardiac Mechano-Signaling. Frontiers in bioengineering and biotechnology vol. 7 55. 27 Mar. 2019, doi:10.3389/fbioe.2019.00055

K. Chen, A. Vigliotti, M. Bacca, R. M. McMeeking, V.S. Dashpande, J.W. Holmes (2018). Role Of Boundary Conditions In Determining Cell Alignment In Response To Stretch. Proceedings of the National Academy of Sciences of the United States of America vol. 115,5 (2018): 986-991. doi:10.1073/pnas.1715059115

RelatedItems

MCTR

MCTR

High throughput compression stimulation with real-time stiffness measurements

View details...

MCTX

MCTX

High throughput uniaxial compression stimulation

View details...

MCT6-200

MCT6-200

High force uniaxial stimulation of 6 parallel specimens

View details...

MCFX-400

MCFX-400

MechanoCulture FX , 16-well cell culture bioreactor with unaxial stretching and real...

View details...

MCB1-200

MCB1-200

MechanoCulture B1 - Biaxial stimulation of a cells in a monolayer or 3D matrix

View details...

Our Clients Include:

GlaxoSmithKline
University College London
Novartis
Imperial College
University of Cambridge
University of Oxford

Keep in Touch

We promise NEVER to share your details with anyone. You can opt out at any time.