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Dr Andy MacKenzie, University of the West of Scotland

I have had dealings with WPI for several years and have consistently found their customer service to be second-to-none. They have always provided fast and insightful responses to any technical query and such support has been of enormous help to my laboratory.
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Motorized Micromanipulator

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MP-225 Instruction Manual
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MP-225 Drawing
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Micromanipulator Comparison
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  • Highly stable for experiments intolerant of pipette drift
  • Submicron (62.5nm) minimal resolution for fine movement
  • Convenient thumbwheel selects resolution/speed of movement
  • 25mm of motorized travel on all three axes
  • 4th axis for coaxial movement of pipette, angle selected by DIP switches on ROE
  • ROE button press actuates move to Home position for pipette exchange
  • ROE button press actuates move to Work position near recording location
  • Continuous display (in microns) of axes positions located on ROE
  • DIP switches on ROE select direction of movement produced by turn of ROE knob
  • Modularized, compact design easily adaptable to your setup
  • Universal mounting system for headstage or pipette holder
  • Mounting adapters included with manipulator

The MP-225 represents an economical alternative to the MP-285 and MPC-365. In 2002, production and design changes allowed us to produce this motorized manipulator as a more affordable alternative to the industry standart MP-285. While the MP-225 feature set is less comprehensive than the MP-285, it includes the most popular features with an efficient user interface. The mechanical design utilizes a miniature stepper motor and integral anti-backlash gear head. Pre-loaded ball bearing slides provide smooth movement throughout the 25mm of travel. The controller uses low-noise, linear-drive output circuitry identical to that found in the MP-285. The methodology for mounting pipette holders and headstages used with the MP-285 has been maintained in the MP-225 to allow for cross compatibility.

The MP-225 is designed primarily for positioning patch and intracellular recording pipettes. We have retained and refined the features most desired for this type of work. An extended version of the popular rotary optical encoder (ROE) is the sole input device available with the MP-225. Like the MP-285, the manipulator has a synthetic 4th axis for diagonal advancement of the pipette; 16 different angles are selectable via DIP switches. Speed and resolution of movement are easily selected with a multiple position thumbwheel, allowing fast/coarse movement and slow/ultra-fine movement in 10 increments. Two commonly used robotic movements have been incorporated for user convenience. A single button press can initiate a move to a Home position for pipette exchange or to a user defined Work position for quick location of the pipette near the recording location. A display on the ROE gives position location. As all controls are located on the ROE, the controller can be moved to a less accessible area of your setup and does not need to occupy prime space in an equipment rack.




1in | 25mm on all three axes


Six microstep sizes selectable (um/ustep): 0.0625, 0.125, 0.25, 0.5, 1.0 and 2.0
Finer movement settings use the 62.5nm microstep size but fewer microsteps are commanded per encoder knob turn

Maximum Speed


Long Term Stability

1-2 um/hour maximum

Drive Mechanism

Integral miniature stepper motor anti-backlash gearhead


4in x 5.5in x 6in | 10cm x 15cm x 15.5cm

16in x 11in x 3.75in | 40.6cm x 28cm x 9.6cm


2.95lbs | 1.3kg

10lb 11oz/4.5kg


115/230 Volts
50/60 Hertz power line

RoHS Compliant



Arancillo, M., White, J., & Lin, T. (2015). In vivo analysis of Purkinje cell firing properties during postnatal mouse development. Journal of …. Retrieved from

Gianulis, E., & Pakhomov, A. (2015). Gadolinium modifies the cell membrane to inhibit permeabilization by nanosecond electric pulses. Archives of Biochemistry and Biophysics. Retrieved from


Iddings, J., Kim, K., & Zhou, Y. (2015). Enhanced parenchymal arteriole tone and astrocyte signaling protect neurovascular coupling mediated parenchymal arteriole vasodilation in the spontaneously. Journal of Cerebral …. Retrieved from

Pakhomov, A., & Gianulis, E. (2015). Multiple nanosecond electric pulses increase the number but not the size of long-lived nanopores in the cell membrane. … et Biophysica Acta (BBA …. Retrieved from

Pardillo-Díaz, R., Carrascal, L., Ayala, A., & Nunez-Abades, P. (2015). Oxidative stress induced by cumene hydroperoxide evokes changes in neuronal excitability of rat motor cortex neurons. Neuroscience. Retrieved from

Rich, T., Xin, W., Leavesley, S., & Taylor, M. (2015). Channel-Based Reporters for cAMP Detection. cAMP Signaling: Methods and …. Retrieved from

Wu, Y., Wang, L., Ma, J., & Song, Y. (2015). Protein kinase C and Ca2+–calmodulin-dependent protein kinase II mediate the enlarged reverse INCX induced by ouabain-increased late sodium current in rabbit. Experimental …. Retrieved from

Xenias, H., & Ibáñez-Sandoval, O. (2015). Are striatal tyrosine hydroxylase interneurons dopaminergic? The Journal of …. Retrieved from




Huxley-Wall Style Micromanipulator

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One MP-285 manipulator mechanical, one MPC-200 controller, one ROE-200, mounting ada...

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