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DS8000

DS8000

The DS8000 Digital Stimulator - 8 channel has been discontinued - please contact your local office for further info

  • Overview
  • Specifications
  • Accessories
  • Citations
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Overview

DS8000 has been discontinued

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Data Sheet
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This unit has been discontinued, but demonstration models may still be available.

  • Single board computer with LCD touch screen
  • Scope mode displays waveforms
  • 8 banks of 3 timers, synchronous/asynchronous
  • 8 internal and 8 external trigger inputs
  • 32 separate outputs ( 24 BNC's on the front panel)

The DS8000 represents a quantum leap in the performance of the research stimulator, and is the most advanced stimulator on the market. With a built-in computer, the entire waveform is generated digitally with precision timing. The DS8000 can generate stimulating wave patterns of a complexity unmatched by any other instrument on the market. A built in digital oscilloscope allows the user to preview waveforms on the LCD. An Ethernet connection allows the user to transfer custom waveforms and upgrade the software using TCP/IP protocol via remote access.

Outputs, Inputs, and Waveforms

The DS8000 has 8 analog outputs, 8 TTL outputs and 8 combined analog or TTL outputs. Each combined output can be comprised of a combination of any of 1 to 8 channels. Eight independent internal timers and eight independent external triggers are offered. The built-in waveforms include unipolar, bipolar, and paired pulse, as well as step, sine, ramp and custom. An external trigger, internal analog channel, internal TTL channel, or any of the eight built-in timers can be assigned to control each output channel. A unique feature of the DS8000 is the capability to stimulate with a waveform that is identical or similar to real biopotential wave patterns associated with ECG, EEG or action potentials. A biopotential waveform captured by a data acquisition system may be transferred to an Excel spreadsheet for editing or modification, then loaded into to the DS8000.

Single Board Computer

Although it may be argued that some functions of the DS8000 can be implemented on a standard PC, it is important to recognize that the inherent design of a PC operating system makes the accurate delivery of precision pulse protocols impossible. Despite the fact that PCs are very economical, they are simply not designed to generate highly accurate timing because the microprocessor resources are not prioritized for this function. In addition, analog waveform generation is not readily available without adding expensive output boards and the required programming is non-standard. The DS8000 platform is based on a powerful single board computer that is fully dedicated to the temporal accuracy and precision required in current biological and neurological research. Indeed, the DS8000 Digital Stimulator offers all of these solutions plus Good Laboratory Practices (GLP) compliance for research traceability.Paired Pulse Protocol

The DS8000’s Paired Pulse function allows the user to generate triggered paired pulses (including refractory period) from a single channel without the use of a train function. WPI’s paired pulse algorithm simplifies the arduous repetitive task normally associated with manual resetting of interpulse intervals in refractory studies. Auto-increment eliminates the need to overlap train functions from multiple channels to generate a complete protocol. Thus, there is a significant reduction in setup time and a minimization of the potential for human error during interactive protocol modification.
ch1pp.jpg
Fig. 1-Channel Settings

Fig. 1 shows Channel 1 configured in the TRIGGERED PAIRED PULSE mode. In this example, a dual pulse event occurs synchronously with each trigger pulse from Channel 8, which is set to trigger every 300ms. The initial interpulse interval is set to 20 ms. Subsequent interpulse intervals are automatically incremented by 35 ms for each three consecutive paired pulse events. The resulting paired pulse is displayed in the lower trace on the DS8000 scope (Fig. 2). The upper trace shows the master trigger pulse set up on Channel 8.
ppulse.jpg
Fig. 2-Scope Display

Soft Keys and GUI Interface

The DS8000 employs “soft keys”, which are programmable controls widely used in several menu options to sequentially change the numerical value of any variable waveform parameter. The DS8000’s soft keys are easily recognized as single or double “+” and “-“ signs located adjacent to a parameter value box (Fig.1). Soft keys provide quick and easy access to modify parameter values on the fly during an experiment. The GUI interface (Fig.3) enables the user to assign the incremental value of the soft key to suit the needs of the experiment. Alternatively, a pop-up numeric keypad is accessible for each parameter to program a precise value that is not a multiple of the softkey-preset increment.
gui.jpg
Fig. 3-Graphic User Interface

Combined Channel Assignments Matrices

The CTTL (COMBINED TTL matrix) and CA (COMBINED ANALOG matrix) screens permit the assignment of any combination of the 8 available TTL or Analog signals to any permutation of the respective (8) CTTL or (8) CA BNC outputs. The setup in Fig. 4 indicates that all TTL channels are assigned to their respective CTTL outputs with the exception of the output of CTTL 1, which is assigned a combination of the TTL signals from channels 4 and 5. Changing assignments is as easy as checking the associated box. The CA tab reveals an identical matrix for programming the COMBINED ANALOG BNC outputs.
cttl.jpg

Fig. 4-Combined TTL Matrix

Specifications

Period (total signal width) 0.04 ms to 10,737,418.24 ms
Pulse width 0.02 ms to 10,737,418.24 ms
Bipolar gap width 0.00 ms to 10,737,418.24 ms
Operating Modes Free run, triggered, gated, Train, DC
Triggers 8 External, manual, TTL 1-8, combined TTL 1-8, timer start or stop
Train events 1-199
Train pulse width 0.02 ms to 10,737,418.24 ms (3 hours)
Train pulse DELAY 0.04 ms to 10,737,418.24 ms
Train period 0.06 ms to 10,737,418.24 ms
BNC Output connectors Analog, combined analog, combined digital (TTL )
Waveforms Unipolar, bipolar, rectangular, sine, ramp, step, paired pulse, custom defined
Custom waveform 12 steps/ voltage point (1025 if remote controlled)
VARIABLE step waveform 100 points (1025 if remote controlled)
Output Noise < 5mV rms
Timing Accuracy < 100ppm
OUTPUT Voltage Resolution 5mV
Max. output voltage +/-10V @ +/- 10mA @ 0.005V/step
Output impedance 50 Ohm Analog, < 1 ohm Combined Analog
External TRIGGER sync 40 microsecond minimum pulse TTL , CMOS
Digital I/O 5V max 10 mA (input)
Mains voltage 85-260 V AC, 45-65 Hz 50W
Dimensions 13.3 cm x 42.5 cm x 25.4 cm 5.2" x 16.73" (19" rack) x 10"
SHIPPING Weight 12 lb. (5.5 kg)
Ambient temperature (-10 to +40°C; -20 to +50°C (Internal)
Humidity Max. 5% relative humidity, non-condensing
Notes PECIFICATIONS SUBJECT TO CHANGE WITHOUT NOTICE.

Accessories

DLS100

DLS100

Digital Linear Stimulus Isolator for use with DS8000 only - discontinued item, please c...

View details...

Citations

Boger, A. (2012). High frequency sacral root nerve block allows bladder voiding. Neurourology and  …. Retrieved from https://onlinelibrary.wiley.com/doi/10.1002/nau.21075/full

Dijk, A. van, Klanker, M., & Oorschot, N. van. (2013). Deep brain stimulation affects conditioned and unconditioned anxiety in different brain areas. Translational  …. Retrieved from https://www.nature.com/tp/journal/v3/n7/abs/tp201356a.html

Harvey, B., Siok, C., Kiss, T., & Volfson, D. (2013). Neurophysiological signals as potential translatable biomarkers for modulation of metabotropic glutamate 5 receptors. …. Retrieved from https://www.sciencedirect.com/science/article/pii/S0028390813002888

Hou, L., Hu, B., & Jalife, J. (2013). Genetically Engineered Excitable Cardiac Myofibroblasts Coupled to Cardiomyocytes Rescue Normal Propagation and Reduce Arrhythmia Complexity in. PloS one. Retrieved from https://dx.plos.org/10.1371/journal.pone.0055400

Kaur, K., & Zarzoso, M. (2013). TGF-β1, Released by Myofibroblasts, Differentially Regulates Transcription and Function of Sodium and Potassium Channels in Adult Rat Ventricular. PloS one. Retrieved from https://dx.plos.org/10.1371/journal.pone.0055391

MOERS-HORNIKS, V. (2012). c-Fos expression in the deep cerebellar nuclei in a rat model of conditioned fear. JOURNAL OF  …. Retrieved from https://dergi.omu.edu.tr/index.php/JECM/article/view/2230

O’Grady, G. (2012). Rapid high-amplitude circumferential slow wave propagation during normal gastric pacemaking and dysrhythmias. …. Retrieved from https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2012.01932.x/full

Pineda, E., Shin, D., & You, S. (2013). Maternal immune activation promotes hippocampal kindling epileptogenesis in mice. Annals of  …. Retrieved from https://onlinelibrary.wiley.com/doi/10.1002/ana.23898/abstract

Plasse, G. van der, & Schrama, R. (2012). Deep brain stimulation reveals a dissociation of consummatory and motivated behaviour in the medial and lateral nucleus accumbens shell of the rat. PloS one. Retrieved from https://dx.plos.org/10.1371/journal.pone.0033455

Premereur, E., Janssen, P., & Vanduffel, W. (2012). FEF-microstimulation causes task-dependent modulation of occipital fMRI activity. NeuroImage. Retrieved from https://www.sciencedirect.com/science/article/pii/S1053811912011299

Rashid, S., Pho, G., Czigler, M., Werz, M., & Durand, D. (2012). Low frequency stimulation of ventral hippocampal commissures reduces seizures in a rat model of chronic temporal lobe epilepsy. Epilepsia. Retrieved from https://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2011.03348.x/full

Tang, T., Lai, N., Wright, A., & Gao, M. (2013). AVAdenylyl Cyclase 6 Deletion Increases Mortality During Sustained β-Adrenergic Receptor Stimulation. Journal of molecular and …. Retrieved from https://www.sciencedirect.com/science/article/pii/S0022282813001363

Temel, Y., Blokland, A., & Lim, L. (2012). Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal. Behavioural Brain Research. Retrieved from https://www.sciencedirect.com/science/article/pii/S0166432812003671

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