MCT6-306

Overview

• Uniaxial tension stretch conditioning in culture
• Up to 6 specimens in parallel
• High force tension stimulation (up to 200 N)
• Grip separation up to 80 mm
• PC-independent incubator operation
• Autoclavable culture-contacting components

The MechanoCulture T6 (MCT6) is a tension-stimulation system designed for long-duration culture experiments where controlled stretch is the stimulus and biological response is the output. It delivers repeatable uniaxial stretch stimulation to clamp-mounted constructs and soft tissues, with PC-independent operation for incubator-based studies.

This tension stimulation system is widely used as a tissue engineering bioreactor for structural constructs where controlled strain is applied over hours to days in an incubator. As a high-force uniaxial stimulation platform, the MCT6 is commonly selected when specimen gripping, high load capacity, and long grip separation are required for tissue engineering and mechanobiology setups. Researchers use it to apply cyclic and intermittent regimens that support mechanotransduction, maturation, and durability-oriented conditioning.

The MechanoCulture T6 can uniaxially stretch up to 6 clamp-mounted specimens from 5-80mm in length. For stimulation in tendon, ligament, and bone tissue engineering work, it can deliver up to 200N of thrust. For cardiovascular research, the system can stimulate at up to 2Hz.

All components in contact with the culture can be autoclaved and the device can be run inside an incubator environment. Stainless steel grips secure the specimens at each end. The spacing and geometry of these grips can be customized to suit a variety of specimen sizes and materials.

The MechanoCulture T6 can be programmed to run constant velocity or sinusoidal stretch patterns. Magnitudes, frequencies, rest periods, and cycle counts can all be specified in the software application and programmed to the device.

MechanoCulture T6 6-Well (MCT6-306) 

A mechanical stimulation bioreactor configuration with 6 individual wells/channels. This format supports separation between specimens when different media, conditions, or sample isolation is required. Best for: mechanotransduction screening across media conditions, parallel cohorts, and tissue engineering bioreactor workflows where channel separation reduces cross-talk

 

What's Included

• Programming software (lifetime license)
• 6 sets of specimen grips
• Controller for up to 200 N uniaxial tension stimulation

Videos

 

Specifications

Specification	MCT6 Standard (MCT6-200)	MCT6 6-Well (MCT6-306)
Stimulation Mode	Uniaxial tension	Uniaxial tension
Specimen Capacity	Up to 6 specimens	Up to 6 specimens
Culture Format	Shared bath environment	6 individual wells/channels
Specimen Size	From 5 to 80 mm length	From 5 to 80 mm length
Loading Capacity	200 N	200 N
Media Volume	100-300 mL	100-300 mL
Grip Separation	Up to 80 mm	Up to 80 mm
Max Stretch	25 mm	25 mm
Max Velocity	20 mm/s	20 mm/s
Max Cycle Frequency	2 Hz	2 Hz
Autoclavable components	Yes	Yes
Dimensions	36 X 15 X 9 cm	36 X 15 X 9 cm
Weight	3 Kg	3 Kg
Common Uses	Tendon, ligament, musculoskeletal, and structural tissue constructs	Parallel cohorts requiring media separation or reduced sample cross-talk

Accessories

Citations

James Britton, Katarzyna Krukiewicz, Malu Chandran, Jorge Fernandez, Anup Poudel, Jose-Ramon Sarasua, Una FitzGerald, Manus J.P. Biggs, (2021). A flexible strain-responsive sensor fabricated from a biocompatible electronic ink via an additive-manufacturing process. Materials & Design, Volume 206, 2021, 109700, ISSN 0264-1275, https://doi.org/10.1016/j.matdes.2021.109700.

Marc A. Fernandez-Yague,Alexandre Trotier,Secil Demir,Sunny Akogwu Abbah,Aitor Larrañaga,Arun Thirumaran,Aimee Stapleton,Syed A. M. Tofail,Matteo Palma,Michelle Kilcoyne,Abhay Pandit,Manus J. Biggs (2021). A Self-Powered Piezo-Bioelectric Device Regulates Tendon Repair-Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels.

Kailei Xu1,2,3†, Xixia Liu 2,3,4†, Xiaokeng Li 2,3, Jun Yin2,3, Peng Wei5, Jin Qian6* and Jie Sun1,7 (2021). Effect of Electrical and Electromechanical Stimulation on PC12 Cell Proliferation and Axon Outgrowth.

Hyeree Park, Showan N. Nazhat, Derek H. Rosenzweig (2021). Mechanical activation drives tenogenic differentiation of human mesenchymal stem cells in aligned dense collagen hydrogels. bioRxiv 2021.11.25.470026; doi: https://doi.org/10.1101/2021.11.25.470026

Alejandro Garcia Garcia,Jean-baptiste Perot,Megane Beldjilali-Labro,Quentin Dermigny,Marie Naudot,Sophie Le Ricousse,Cecile Legallais,Fahmi Bedoui (2021). Monitoring mechanical stimulation for optimal tendon tissue engineering: A mechanical and biological multiscale study. Journal of biomedical materials research. Part A vol. 109,10 (2021): 1881-1892. doi:10.1002/jbm.a.37180

Lin, J., Li, X., Yin, J. and Qian, J. (2020). Effect of Cyclic Stretch on Neuron Reorientation and Axon Outgrowth. Frontiers in bioengineering and biotechnology vol. 8 597867. 14 Dec. 2020, doi:10.3389/fbioe.2020.597867

Fernandez-Yague, M.A., Trotier, A., Abbah, S.A., Larrañaga, A., Thirumaran, A., Stapleton, A., Tofail, S.A., Palma, M., Pandit, A. and Biggs, M.J. (2020). Self-powered piezo-bioelectronic device mediates tendon repair through modulation of mechanosensitive ion channels. bioRxiv 2020.08.03.227868; doi: https://doi.org/10.1101/2020.08.03.227868

D. Kumar, S. A. Cain, L. A. Bosworth (2019). Effect Of Topography And Physical Stimulus On Hmsc Phenotype Using A 3d In Vitro Model. Nanomaterials (Basel, Switzerland) vol. 9,4 522. 3 Apr. 2019, doi:10.3390/nano9040522

J. Bracamonte, S. Saunders, S. Cole, G. Annohene, G. Tepper, J. Soares (2019). In vitro degradation of electrospun polycaprolactone tissue engineering scaffolds under cyclical dynamic loading.

D. Gaspar, Christina N. M. Ryan, Dimitrios I. Zeugolis (2019). Multifactorial Bottom-Up Bioengineering Approaches For The Development Of Living Tissues Substitutes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 33,4 (2019): 5741-5754. doi:10.1096/fj.201802451R

M. S. Ali, X. Wang, C. M. R. Lacerda (2019). The Effect Of Physiological Stretch And The Valvular Endothelium On Mitral Valve Proteomes. Experimental biology and medicine (Maywood, N.J.) vol. 244,3 (2019): 241-251. doi:10.1177/1535370219829006

Mir Ali (2018). Mechanotransduction And Control Of Valvular Cell Phenotype As Tools To Inform Valvular Pathophysiology.

S. Wu, Y. Wang, P.N. Streubel, B. Duan (2017). Living Nanofiber Yarn-Based Woven Biotextiles For Tendon Tissue Engineering Using Cell Tri-Culture And Mechanical Stimulation. Acta biomaterialia vol. 62 (2017): 102-115. doi:10.1016/j.actbio.2017.08.043

F. Chen, G. Hochleitner, T. Woodfield, J. Groll, P. Dalton, B.G. Amsden (2016). Additive Manufacturing Of A Photo-Cross-Linkable Polymer Via Direct Meld Electrospinning Writing For Producing High Strength Structures. Biomacromolecules vol. 17,1 (2016): 208-14. doi:10.1021/acs.biomac.5b01316

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