EVM-MT-03-01

Overview

EVOM™ Manual For TEER Measurement with automatic data logging

The EVOM™ Manual delivers improved workflow efficiency, more stable and repeatable measurements versus traditional Trans Epithelial Electrical Resistance (TEER) meters. Providing users with vital feedback during experiment measurements, the EVOM™ Manual’s large screen offers a range of informational views. The new graphical displays for trend analysis and measurement values helps scientists deliver simple, stepwise methodology during experimental measurements. The touch screen interface provides you with an intuitive, easy-to-use menu for configuration.

Eliminating the need to log data by hand, the EVOM™ Manual writes the resistance or voltage information to a USB drive in CSV format for easy transfer to spreadsheets and data analysis programs. When used with the footswitch it enables handsfree recording of measurements.

At the heart of the EVOM™ Manual is our latest processor and circuitry, providing users with quick, easy and reliable readings due to its fast stabilization, automatic twenty times sampling average and low noise design. The auto ranging resistance feature allows for fast resistance measurements, and an over-range display feature eliminates false readings. The EVOM™ Manual has adjustable current levels in three fixed ranges with two lower ranges for sensitive membranes and high resistance ranges up to 100 KΩ.

• Low noise design offers greater resolution and accuracy
• Automatic 20X sample averaging improves accuracy and stability
• Adjustable fixed measurement currents (2, 4 or 10 μA)
• Resistance auto ranging from 1 Ω to 100,000 Ω or with three fixed current ranges
• Reliable low current, low voltage design prevents metal ion transport
• Fast resistance stabilization on low levels under 200 Ω with resolution to 0.1 Ω
• Ergonomic tilt stand for low glare operation
• Graphical display of popular plates (6, 12, 24, 96) for trend analysis
• The display shows the most recent set of parameters
• Automatic plate indexing operation with or without control well subtraction for resistance and potential difference (PD) measurements
• Continuous data logging via USB (PC, Mac, Linux)
• Saves date stamped data to a spreadsheet readable file on a USB drive
• Upgradable firmware
• Upgrade of the EVOM3, in the trusted family of the EVOM™ brand of TEER measurement products

 Benefits

• Eliminates errors and reduces experimental processing time
• Auto data logging eliminates the need to track data by hand
• The small footprint allows more bench space
• Easy calibration and verification
• Footswitch for hands-free recording
• Prevent data loss with auto save and data recovery when battery is low
• TEER is easily computed by applying a unit area formula to the resistance

Applications

• Measure epithelial or endothelial tissues for confluence, TEER and potential difference
• Permeability, conductance and drug studies
• Continuous digital monitoring of a target membrane
• Common studies
• Blood-brain barrier transport
• Lung epithelial tissue studies
• Intestinal tissue studies
• Skin studies

How Does the EVOM™ Manual Work?

Confluence of a cellular monolayer is determined by an increase or a plateau in tissue resistance detected using the unique electronic circuit of the EVOM™ Manual and the new STX4 electrode. The EVOM™ Manual qualitatively measures cell monolayer health and quantitatively measures cell confluence. The EVOM™ Manual produces a low AC current that avoids electrode metal deposits and adverse effects on tissues which can otherwise be caused by higher DC currents. The EVOM™ Manual uses low current and voltages and is designed for non-destructive testing for epithelial monolayer confluence in cell cultures. In addition, resistance readings are unaffected by membrane capacitance or membrane voltage. The accuracy and repeatability of the EVOM™ Manual-STX4 system makes this instrument ideal for permeability, PD and other detailed membrane studies.

System Components

What is included with the EVOM™ Manual	QTY
EVOM™ Manual Epithelial Volt Ohm Meter	1
300749 USB drive 32 GB (Used for storage. Also contains a Python 3.8 program for continuous digital monitoring of a target insert).	1
503535 USB cable	1
99673 Calibration kit, 1000Ω Test Resistor	1
803025 A/C power cord and charger	1
13142 Foot switch	1

NOTE: A 99672 EVOM2 to EVOM Manual Electrode Adapter is sold separately. The STX2 and STX3 require the use of this adapter with the EVOM3 or EVOM Manual.

Select an electrode or endohm listed below to complete the system.

Electrodes For TEER (Epithelial) Measurement

Part #	Descriptions
EVM-EL-03-03-01	STX4 EVOM™ Electrode with Removable Blades for TEER in 6.5 mm Inserts
EVM-EL-03-03-05	STX HTS EVOM™ Electrode for EVOM Manual, use with Corning HTS 96-Well Plate
EVM-EL-03-03-02	STX HTS EVOM™ Electrode for EVOM Manual, use with Millipore Multiscreen HTS 96-Well Plate
EVM-EL-03-03-03	STX HTS EVOM™ Electrode for EVOM Manual, use with Corning Biocoat/Falcon HTS Multi 24-Well Insert System
EVM-EL-03-03-04	STX HTS EVOM™ Electrode for EVOM Manual, use with Corning Costrar HTS Multi 24-Well Insert System
STX2*	Replacement Electrode Set (Requires 99672 for use with the EVOM Manual)
STX3*	Adjustable electrode set for shallow wells, 5-9 mm depth
3993*	2 mm Adapter for EVOM meters

*Requires 99672 for use with the EVOM Manual

ENDOHM Chambers For Endothelial/Epithelial Measurement

NEW EndOhm chambers include the EVOM3 cable 99916.

Part #	Descriptions
EVM-EL-03-01-01	ENDOHM-6 EVOM™ Electrode for TEER in 6.5 mm Insert / culture cup (24 wells per plate)
EVM-EL-03-01-02	ENDOHM-12 EVOM™ Electrode for TEER in 12 mm Insert / culture cup (12 wells per plate)
EVM-EL-03-01-03	ENDOHM-24 EVOM™ Electrode for TEER in 24 mm Insert / culture cup (6 wells per plate)

 

Compatible Electrodes & Accessories

EVOM™ Manual Videos

Nine Reasons To Trust WPI's EVOM™ Manual TEER Meter

Unboxing the EVOM™ Manual TEER Meter

Common Applicatons For The EVOM™ Manual

Why Upgrade your EVOM Manual?

 

EVOM™ Manual Electrode Options

 

Quick Start Guide for the EVOM Manual Home Screen

 

EVOM™ Manual Monitors Cellular Health by Measuring TEER/TER

 

How to Take Voltage Measurements with the EVOM™ Manual

 

How to Take Resistance Measurements with EVOM™ Manual

Resources

EVOM™ Manual Articles Reference publications, white papers and application notes for TransEpithelial Electrical Resistance TEER measurement

Specifications

Accessories

Citations

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